|
KMID : 1149120210180020043
|
|
Journal of the Korean Society for Psoriasis
2021 Volume.18 No. 2 p.43 ~ p.45
|
|
|
A Case of Reactivation of Latent Tuberculosis during Biologics Treatment in a Patient with Psoriasis
|
|
Kim Chang-Yong
Cho Young-Ah
Kim Sung-Min
Hong Ji-Youn
Lee Yang-Won
Ahn Kyu-Joong
Choe Yong-Beom
|
|
|
Abstract
|
|
|
|
A 44-year-old male patient with a 15-year history of plaque-type psoriasis visited our dermatologic clinic. In screening tests for latent tuberculosis (TB) infection, both interferon-gamma release assay and purified protein derivative skin test showed positive results. As chest radiography showed no specific findings and the patient had no respiratory symptoms, isoniazid was administered for 9 months. For the treatment of psoriasis, ustekinumab was started. The patient was treated with ustekinumab for 5 years followed by secukinumab for 47 weeks. Thereafter, owing to a decrease in drug efficacy, guselkumab was started. At 21 weeks after treatment with guselkumab, a chest radiograph showed findings suspicious for TB. Subsequent chest computed tomography revealed active TB, and the patient was referred to a pulmonologist for further evaluation. Biologics are considered safe for the treatment of psoriasis. However, in patients with long-term administration of multiple biologics, the risk of TB reactivation should not be overlooked.
|
|
|
KEYWORD
|
|
|
Biologics, Latent tuberculosis, Psoriasis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|